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S-2238 is a chemically synthesized thrombin (Factor IIa, FXa)-specific substrate.
Company Name :
Beijing Asnail Biotechnology Co.LtdBrand :
AsnailFounded in 2017, Beijing Asrael Biotechnology Co., Ltd. has a business scope that includes the R&D and production of laboratory instrument consumables, animal blood products and product development in the diagnostic reagent industry.
In the direction of laboratory instrument consumables, for the three industrial directions of biotechnology and pharmaceutical industry, thrombosis and hemostasis industry and automotive polymer materials industry, Asrael screens out the corresponding combination of instruments and equipment, reagent consumables.
We adhere to the business philosophy of "professional first, honesty and trustworthiness", provide professional services and high-quality products for customers in related fields, shorten the process of customer procurement, improve efficiency, save costs, and strive to become a stable supplier trusted by customers.
Asrael's business objectives are:
We do not seek to be the largest in the industry, but rather to be the one that endures the longest.
We do not seek the fastest cooperation with clients, but rather the most enduring.
①Heparinases
Heparinases can clave glycosidic bonds of heparin and/or heparan sulfate by a β-elimination mechanism, generating unsaturated products (mostly
disaccharides) with a double bond be-tween C4 and C5 of the uronate residue.
Features:
● Natural heparinase, from Flavobacterium heparinum.
● It has the highest specific activity compare with other products on the market.
● Pure enzyme, free of BSA or other protein impurities.
● Good stability, consistent batch reproducibility and degradation characteristics.
②TOSOH TSKgel SWXL Columns
Tosoh SWxl series columns feature high porous volume/unit volume ratio, low sample absorption, and high column efficiency. Could be used for MW
determinations of heparin and LMWHs.
③BioCore™ SEC columns
Asnail co-developed the BioCore SEC-HP columns, tailored for molecular weight (MW) and MW distribution. The column is durable and can provide
better volume exclusion separation.
④Dionex™ IonPac™ AS11 IC Columns
The Column specifically designed to resolve a large number of inorganic anions and organicacid anions from a single sample injection in one gradient run using hydroxide eluent systems.USP officially specifies the method for the identification of heparin sodium chromatography.
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Product Information
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Details
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Place of Origin
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China
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Brand
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Asnail
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Goods Number
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AS00 - 0101
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Usage
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Chromogenic substrate S-2238 for thrombin has a wide range of uses, such as: detecting the ratio of anti-FXα activity to anti-Flla activity of unfractionated heparin and low-molecular-weight heparin, accurately detecting anti-Flla activity in both types of heparin
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Packaging Specification
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25mg
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CAS Number
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113711-77-6
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Purity
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98%
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Is it Imported
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No
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Form & Composition
S-2238 is lyophilized.
Main ingredients: S-2238 10 mg, about 15 μmol;
Filler: mannitol 120 mg
Physical and chemical properties
CAS Registry Number: 113711-77-6
Molecular Formula: H-D-Phe-Pip-Arg-pNA·2HCl
Molecular weight: 625.6 Da
Purity: ≥ 98% (HPLC)
Absorbance coefficient (405 nm): ≤0.120 [L/(g·cm)]
Solubility: > 10 mg/ml in purified water
How to use
According to the application requirements, an appropriate amount of water for injection or buffer solution was added to obtain the required concentration of S-2238 solution.
Stability and storage method
S-2238 lyophilized product should be stored at 2-8°C in the dark, and the expiration date should be more than 24 months;
3 mmol/L S-2238 solution was stored at 2-8°C in the dark, and the expiration date was more than 1 month.
Precautions
S-2238 is intended for use in the detection of heparin anti-FIIa activity and should only be used for laboratory scientific research, in vitro diagnostics and industrial quality control, and should not be used as a drug or in vivo diagnosis.
Application examples
The thrombin chromogenic substrate S-2238 has a wide range of uses, such as:
The anti-FXa activity and anti-FIIa activity ratio of unfractionated heparin and low molecular weight heparin were tested
Accurate detection of anti-FIIa activity of unfractionated heparin and low molecular weight heparin
To evaluate the anti-FIIa activity of chemically synthesized substances or tissue extracts
The concentration of antithrombin in a blood sample is measured to diagnose antithrombin deficiency
The concentration of heparin in the blood is monitored during the procedure
Production of kits for automated hematology analyzers
Ordering Information
Catalog number: AS00-0101
Packing: 25mg
Delivery: In stock
About the Hair Color Substrate Method
chromogenic substrates are chemically synthesized small peptides with a chromogenic group (pNA) at one end. Specific enzymes, such as thrombin, catalyze the separation of pNA. Free pNA can be detected by spectrophotometer or microplate reader to determine the activity of the corresponding substance.
Common chromogenic substrates are: thrombin pigment substrate S-2238, FXa chromogenic substrate S-2765 and S-2222.
Chromogenic assays are the main heparin titer detection methods, which are prescribed by the European Pharmacopoeia (EP) and the United States Pharmacopoeia (USP) for the detection of heparin (especially low molecular weight heparin). This method is also widely used in laboratory studies and in vitro diagnostics.
By controlling the conditions of the reaction system, the chromogenic substrate method can detect coagulation factors, cofactors, or inhibitors of coagulation factors.
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